Repeatmediated deletions can be induced by a chromosomal break far from a repeat, but multiple pathways suppress such rearrangements (MendezDorantes C 18) Breakinduced replication plays a prominent role in longrange repeatmediated deletion Brian Luke Kellner and Luke review how RNase H2 or topoisomerase enzymes remove misincorporated ribonucleotides from genomic DNA, and the relevance of such mechanisms for both malignant and autoimmune diseases such as Aicardi–Goutières syndrome EWS removes PARP1 from damaged DNA, and abnormal retention of PARP1 due to the loss of EWSBreakinduced replication plays a prominent role in longrange repeatmediated deletion View PDF In The EMBO Journal on 16 December 19 by Hu, Q, Lu, H, et al Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27 View PDF
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