Repeatmediated deletions can be induced by a chromosomal break far from a repeat, but multiple pathways suppress such rearrangements (MendezDorantes C 18) Breakinduced replication plays a prominent role in longrange repeatmediated deletion Brian Luke Kellner and Luke review how RNase H2 or topoisomerase enzymes remove misincorporated ribonucleotides from genomic DNA, and the relevance of such mechanisms for both malignant and autoimmune diseases such as Aicardi–Goutières syndrome EWS removes PARP1 from damaged DNA, and abnormal retention of PARP1 due to the loss of EWSBreakinduced replication plays a prominent role in longrange repeatmediated deletion View PDF In The EMBO Journal on 16 December 19 by Hu, Q, Lu, H, et al Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27 View PDF
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Break-induced replication plays a prominent role in long-range repeat-mediated deletion
Break-induced replication plays a prominent role in long-range repeat-mediated deletion- Figure 1 Model of RAD51Dependent BreakInduced Replication (BIR) (A) Following doublestrand break resection, the 3′ singlestrand DNA (ssDNA) end invades a homologous DNA molecule to form a displacement loop (Dloop) and DNA synthesis is initiated (possibly with participation of Polα) at the 3′ invaded end Breakinduced replication plays a prominent role in longrange repeatmediated deletion Hu Q, Lu H, Wang H, Li S, Truong L, Li J, Liu S, Xiang R, Wu X EMBO J, 38(24)e, Cited by 1 article PMID
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Breakinduced replication plays a prominent role in longrange repeatmediated deletion View PDF In The EMBO Journal on 16 December 19 by Hu, Q, Lu, H, et al Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro Masaki Matsumoto Pratibha Srivastava Arpit Katiyar Keiich I Nakayama Akira Nakai Shugoshin 2 is a new cofactor for heat shock factor 1 and facilitates recruitment of RNA polymerase II to stressinducible promoters Abstract Full text PDFBreakinduced replication plays a prominent role in longrange repeatmediated deletion View PDF In The EMBO Journal on 16 December 19 by Hu, Q, Lu, H, et al ERCC1/XPF Is Important for Repair of DNA DoubleStrand Breaks Containing Secondary Structures View PDF
The breakcopy mode of recombination (as opposed to breakjoin), was initially proposed by Meselson and Weigle ()Breakcopy recombination, now more commonly known as recombinationdependent DNA replication or breakinduced replication (BIR), is believed to account for restarting replication at broken replication forks and may also play a central role in the The role of Rad5 at short CAG repeats (eg less than 35 repeats) was epistatic to a deletion of SRS2, implicating a role for the Srs2 helicase, which was hypothesized to unwind 3′ hairpins occurring during the template switch , Altogether, these data indicate that CAG tracts induce both SCR and template switch events, and that in yeast1995 1996 Postdoctoral Fellow , Brandeis University Dr Xiaohua Wu studies the molecular mechanisms that regulate DNA repair and cell cycle checkpoint control in mammalian cells with an emphasis on how these activities contribute to the maintenance of genome stability and the prevention of cancer
Conventionally, single‐strand annealing (SSA) is thought to mediate homology‐directed repair of double‐strand breaks (DSBs) between two repeats, causing repeat‐mediated deletion (RMD) In this report, we demonstrate that break‐induced replication (BIR) is used predominantly over SSA in mammalian cells for mediating RMD, especially when repeats are far apartBreakinduced replication plays a prominent role in longrange repeatmediated deletion Repetitive DNA sequences are often associated with chromosomal rearrangements in cancers Conventionally, single‐strand annealing (SSA) is thought to mediate homology‐directed repair of double‐strand breaks (DSBs) between two repeats, causing repeat‐mediated deletion (RMD) In this report, we demonstrate that break‐induced replication (BIR) is used
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Strand breaks (DSBs) between two repeats, causing repeatmediated deletion (RMD) In this report, we demonstrate that breakinduced replication (BIR) is used predominantly over SSA in mammalian cells for mediating RMD, especially when repeats are far apart We show that SSA becomes inefficient in mammalian cells when the distanceScopus (7) Google Scholar, MendezDorantes et al, 18 MendezDorantes C Bhargava R Stark JMBreakinduced replication (BIR) repairs oneended doublestrand breaks in DNA similar to those formed by replication collapse or telomere erosion, and it has been implicated in the initiation of
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Yang, J, Liao, D B, Chen, C, Liu, Y, Chuang, T H, Xiang, R, Markowitz, D, Reisfeld, R A, Luo, Y P Tumorassociated macrophages regulate murine breastSUMMARY Repeatmediated deletions (RMDs) often involve repetitive elements (eg, short interspersed elements) with sequence divergence that is separated by several kilobase pairs (kbps) We have examined RMDs induced by DNA doublestrand breaks (DSBs) under varying conditions of repeat sequence divergence (identical versus 1% and 3% divergent) and DSB/repeat distance (16Breakinduced replication (BIR) is an important pathway specializing in repair of oneended doublestrand DNA breaks (DSBs) This type of DSB break typically arises at collapsed replication forks or at eroded telomeres BIR initiates by invasion of a broken DNA end into a homologous template followe
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In this report, we demonstrate that breakinduced replication (BIR) is used predominantly over SSA in mammalian cells for mediating RMD, especially when repeats are far apart We show that SSA becomes inefficient in mammalian cells when the distance between the DSBs and the repeats is increased to the 12 kb range, while BIRmediated RMD (BIR/RMD) can Breakinduced replication plays a prominent role in longrange repeatmediated deletion Hu Q, Lu H, Wang H, Li S, Truong L, Li J, Liu S, Xiang R, Wu X EMBO J, 38(24)e, Cited by 6 articles PMID PMCID PMC Free to readBreakinduced replication plays a prominent role in longrange repeatmediated deletion EMBO J 19;
Break Induced Replication Plays A Prominent Role In Long Range Repeat Mediated Deletion The Embo Journal
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Breakinduced replication plays a prominent role in longrange repeatmediated deletion Hu Q, Lu H, Wang H, Li S, Truong L, Li J, Liu S, Xiang R, Wu X EMBO J, 38(24)e, Cited by 6 articles PMID PMCID PMC Free to read Cremediated deletion of the DNA Ligase IV gene was Break‐induced replication plays a prominent role in long‐range repeat‐mediated deletion XLF and H2AX function inBreakinduced replication (BIR) is a pathway that repairs oneended doublestrand breaks (DSBs) For decades, yeast model systems offered the only opportunities to study eukaryotic BIR These studies described an unusual mode of BIR synthesis that is carried out by a migrating bubble and shows conservative inheritance of newly synthesized DNA
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Abstract Repetitive DNA sequences are often associated with chromosomal rearrangements in cancers Conventionally, singlestrand annealing (SSA) is thought to mediate homologydirected repair of doublestrand breaks (DSBs) between two repeats, causing repeatmediated deletion (RMD)Publications Breakinduced replication plays a prominent role in longrange repeatmediated deletion Qing Hu, Hongyan Lu, Hongjun Wang, Shibo Li,Repeatmediated DNA deletion (RMD) is frequently associated with oncogenic chromosomal rearrangements and conventionally occurs via singlestrand annealing (SSA) However, mammalian cells appear to prefer breakinduced replication (BIR) over SSA for recombination between repeatassociated doublestrand breaks (DSBs)
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Breakinduced replication plays a prominent role in longrange repeatmediated deletion Qing Hu, Hongyan Lu, Hongjun Wang, Shibo Li, Lan Truong, Jun Li, Shuo Liu, Rong Xiang, Xiaohua Wu> ;The EMBO Journal 19 Dec 16 7 citations miR30 disrupts senescence and promotes cancer by targeting both p16 INK4A and DNA damage pathwaysBreakinduced replication plays a prominent role in longrange repeatmediated deletion EMBO J 38 e 8 Ma, Q, et al Targeting Ku86 enhances Xrayinduced radiotherapy sensitivity in serous ovarian cancer cells Int J BiochemBreakinduced replication plays a prominent role in longrange repeatmediated deletion
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Breakinduced replication plays a prominent role in longrange repeatmediated deletion EMBO J 38 e Li, S*, Lu, H*, Wang, Z*, Hu, Q, Wang, H, Xiang, R, Chiba, T, and Wu, X (19) XPF is important for repair of DNA doublestrand breaksBreakinduced replication (BIR) is a pathway that repairs oneended doublestrand breaks (DSBs) For decades, yeast model systems offered the only opportunities to study eukaryotic BIR These studies described an unusual mode of BIR synthesis that is carried out by a migrating bubble and shows conseLu S, Liu S, Cui J, Liu X, Zhao C, Fan L, Yin S, Hu H Combination of patulin and chlorpyrifos synergistically induces hepatotoxicity vicsjafc9b 052
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Repair leading to gene conversion (GC) and BreakInduced Replication (BIR) (1) SSA occurs through annealing of DNA direct repeats (orange lines) after they become singlestranded Annealing leads to the deletion of all sequences between the repeats and to the loss of one repeat 37 (2) Gap repair leading to GC GC may proceed via the formation ofBreakinduced replication (BIR) is a pathway that repairs oneended doublestrand breaks (DSBs) For decades, yeast model systems offered the only opportunities to study eukaryotic BIR These studies described an unusual mode of BIR synthesis that is carried out by a migrating bubble and shows conservative inheritance of newly synthesized DNA, leading to genomic instabilities like4 Hu, Q, et al 19 Breakinduced replication plays a prominent role in longrange repeatmediated deletion EMBO J 38 e 5 Qian, Y, et al PAK1 silencing is synthetic lethal with Cdk4/6 inhibition in gastric cancer cells via regulating PDK1 expression Hum Cell 33 RESEARCH USE
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Break‐induced replication plays a prominent role in long‐range repeat‐mediated deletion Qing Hu, Hongyan Lu, Role for histone H2AX in maintaining genomic stability Breakinduced replication plays a prominent role in longrange repeatmediated deletion Hu Q, Lu H, Wang H, Li S, Truong L, Li J, Liu S, Xiang R, Wu X EMBO J, 38(24)e, Cited by 1 article PMID4 Hu, Q, et al 19 Breakinduced replication plays a prominent role in longrange repeatmediated deletion EMBO J 38 e 5 Ohba, S, et al Phosphoglycerate mutase 1 activates DNA damage repair via regulation of WIP1 activity Cell Rep 31 RESEARCH USE For research use only, not for use in diagnostic procedures
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Loop Qing Hu
Multiple functions of breakinduced replication (BIR) One of the major types of spontaneous DNA damage is a singlestranded nick When a replication fork encounters a nick, a singleended doublestrand break is formed and needs to be repaired by homologous recombination (HR) DNA singleend substrates for HR can also form at chromosome ends inProtein Names DNA repair protein RAD51 homolog 1, RAD51 homolog A, RAD51_HUMAN UniProt Code History
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